Keratinocytes and collagen production – new possibilities for skin regeneration

Keratinocytes, the miracle cells. Groundbreaking research published in Nature Communications (February 24, 2025) sheds new light on the process of collagen production in the skin, pointing to the key role of keratinocytes. New methods of stimulating these cells could open the door to new methods of skin regeneration and anti-aging. What are the findings and what potential benefits will they bring to cosmetology and aesthetic medicine? In this article, we’ll discuss the details of the study, its significance and potential for practical application. If you are interested in innovations in skin care, keep reading!

What are they and why are they important?

These are the main cells of the epidermis, responsible for forming the skin’s protective layer and producing keratin. Traditionally, it was thought that type I collagen in the dermis was produced exclusively by fibroblasts – mesenchymal cells. However, research by Ohashi et al (2025) shows that in axolotl skin, it is keratinocytes that initiate the formation of collagen fibers, while fibroblasts merely modify existing fibers. These cells become a new focus of interest, as this mechanism may be universal to humans as well.

What discoveries have been made in axolotl research?

The study used clear axolotl skin and fluorescent collagen probes to examine collagen formation. Key findings:

• Unique cells: they are the ones that start the formation of collagen structures in the dermis.
• Role of fibroblasts: Fibroblasts modify and stabilize already existing fibers, but are not the primary source of collagen.
• Universality of the mechanism: The process is conserved in other model organisms, suggesting that it may also apply to humans.

These discoveries are changing the previous scientific consensus and point to new directions in skin regeneration. The abilities of these cells could revolutionize approaches to anti-aging treatments.

The impact of discovery on aesthetic medicine

1. improved skin regeneration

• How does it work?: Focusing on stimulating epidermal cells can increase natural collagen production.
• Purpose: Treatments such as fractional laser therapy and micropuncture can be tailored to activate epidermal cells, not just fibroblasts.
• Benefits: Faster recovery after treatments, better results in treating scars or stretch marks.

2. new anti-aging therapies

• How does it work?: Products and treatments targeting these cells can promote collagen synthesis, delaying aging.
• Use: Creams and ointments can be designed to promote keratinocyte activity.
• Benefits: Reduction of wrinkles, improvement of skin elasticity and density.

3. treatment after invasive procedures

• How does it work?: An increase in collagen can speed up healing after procedures such as a facelift or skin graft.
• Purpose: Cell stimulation with platelet-rich plasma (PRP) or LED light therapy.
• Benefits: Lower risk of complications, faster return to normal appearance.

The discovery could change the way we approach skin regeneration and rejuvenation.

Potential benefits in cosmetology

New therapies targeting these very cells may also benefit daily care:

• Innovative cosmetics: Products with active ingredients can be formulated to support them in collagen production.
• Better skin protection: Understanding the role of these cells can help develop cosmetics that strengthen the skin barrier.
• Personalization: Genetic tests that assess collagen-forming cell activity can allow customized care.

Is the discovery on axolotls relevant to humans?

The study was conducted on axolotls, but the authors indicate that the mechanism is conserved in other organisms, suggesting a potential application in humans. The axolotl is a valued research model due to its regenerative abilities and clear skin, which has allowed observations impossible in mammals. This may be a universal mechanism, but requires further research on human tissues to confirm these conclusions.

Conclusions of the study

The study by Ohashi et al (2025) brings groundbreaking findings:

• Keratinocytes play a major role in the production of type I collagen, which changes the previous understanding of the process.
• Fibroblasts play a supporting role by modifying existing collagen fibers.
• The mechanism is likely to be universal, paving the way for applications in medicine and cosmetology.

What are the challenges?

Despite the promising findings, there are several challenges:

• Confirmation in humans: tests on human tissues are needed to verify the mechanism.
• Technology adaptation: New methods of stimulating these cells may require years of research and testing.
• Costs: Implementing innovative therapies may initially increase the price of treatments.

But the potential benefits are so great that it is worth investing in further research.

Myths and facts

• Myth: “Animal research has no relevance to humans.”
• Fact: The mechanism is likely conserved in humans, which requires further verification.

Where to look for innovation?

Treatments that stimulate keratinocytes are now available at clinics specializing in aesthetic medicine. These are treatments that work the top layers of the skin, such as fractional laser, Dermapen micro -puncture and micro-needle radiofrequency.

Summary – Keratinocytes in aesthetic medicine

This is a breakthrough discovery that could revolutionize skin regeneration and anti-aging. Potential benefits include improved healing, wrinkle reduction and personalized care. Although further research is needed, this discovery has great potential. Don’t wait – consult an aesthetic medicine expert to find out how these innovations can help your skin!

You can read more about health and beauty HERE. If you need a consultation with our doctors, we invite you to contact us: Call us You can also schedule a visit ON-LINE. Visit us on Instagram and TikTok.

Collagen plays a key role in aesthetic medicine, as it is one of the main structural proteins of the skin, responsible for its firmness, elasticity and hydration. As we age, its natural production declines, leading to wrinkles, loss of elasticity and sagging skin. Therefore, aesthetic medicine uses various methods to supplement its deficiencies or stimulate its natural synthesis.

Injectables, or mesotherapy, are a popular option, and were once one of the first fillers used to smooth wrinkles and improve skin volume. These have now largely been replaced by hyaluronic acid and biostimulants, but are still used in some procedures. Alternatively, treatments that stimulate the skin’s own protein production are used, such as laser therapy, micro-needle radiofrequency, mesotherapy and lifting threads. These technologies work through micro-injuries that stimulate the skin to regenerate and rebuild collagen fibers.

Collagen is also an ingredient in dietary supplements and anti-aging cosmetics, which are designed to improve skin condition from within. Although its effectiveness in the form of creams is limited because large molecules are difficult to penetrate the epidermis, hydrolyzed collagen taken orally can promote the restoration of skin structure.

Modern aesthetic medicine no longer focuses only on supplementing collagen, but primarily on stimulating its natural synthesis, which allows for more long-lasting and natural skin rejuvenation results.